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Efficacy and Cost Effectiveness of Therapeutic Plasma Exchange in patient of Guillain-Barre Syndrome A Prospective study

Dr. M. D. Gajjar, Dr. Sangita D. Shah, Dr. Mamta C.Shah, Dr. Nidhi M. Bhatnagar, Dr. Shital Soni, Dr.Tarak Patel.

Abstract
Introduction: Guillain-Barre syndrome (GBS) is an acute, frequently severe, fulminant poly-radiculoneuropathy that is autoimmune in nature. Current treatment modalities include therapeutic plasma exchange (TPE) and high dose intravenous Immunoglobulin therapy (I.V Ig), both of which involve a high cost. Objectives: To compare the cost effectiveness of plasma exchange over other modalities and to evaluate the clinical benefits of plasma exchange GBS patients. Discussion: In the present study, 100 patients (56 males and 44 females) admitted to the Civil Hospital, Ahmedabad from September 2010 to August 2012 with clinical findings of GBS and/or GBS variants were evaluated. Plasma was exchanged using a Baxter-CS 3000 continuous flow cell separator using double lumen femoral catheter, until a plasma discard of 50ml/kg had been achieved. Cost of treatment with plasma exchange for each patient was compared with other available modalities. Incidence of GBS was found to be more in 11-30 years age group. Male to female ratio was 1.27: 1. Most of the patients underwent 3 cycles of exchange. The result of plasma exchange in terms of improvement in clinical condition of patient was Excellent i.e. more than 85% in 82 patients. No complication was seen in 62 patients and minor complications were observed in 21 patients. The cost of plasma exchange and immunoglobulin treatment were came out to be approximately Rs 30,000/- and Rs. 1, 74,000/- in each patient respectively. Conclusion: Plasma exchange proved to be a better and less costly in the treatment of GBS patient if performed in the first two weeks of onset.

Key words: Guillain-Barre syndrome (GBS), Therapeutic Plasma Exchange (TPE), Intravenous Immunoglobulin (IV Ig)


 
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How to Cite this Article
Pubmed Style

Gajjar DMD, Shah DSD, C.Shah DM, Bhatnagar DNM, Soni DS, Patel D. Efficacy and Cost Effectiveness of Therapeutic Plasma Exchange in patient of Guillain-Barre Syndrome A Prospective study . SEAJCRR. 2013; 2(4): 218-228.


Web Style

Gajjar DMD, Shah DSD, C.Shah DM, Bhatnagar DNM, Soni DS, Patel D. Efficacy and Cost Effectiveness of Therapeutic Plasma Exchange in patient of Guillain-Barre Syndrome A Prospective study . http://www.seajcrr.com//?mno=41062 [Access: December 12, 2017].


AMA (American Medical Association) Style

Gajjar DMD, Shah DSD, C.Shah DM, Bhatnagar DNM, Soni DS, Patel D. Efficacy and Cost Effectiveness of Therapeutic Plasma Exchange in patient of Guillain-Barre Syndrome A Prospective study . SEAJCRR. 2013; 2(4): 218-228.



Vancouver/ICMJE Style

Gajjar DMD, Shah DSD, C.Shah DM, Bhatnagar DNM, Soni DS, Patel D. Efficacy and Cost Effectiveness of Therapeutic Plasma Exchange in patient of Guillain-Barre Syndrome A Prospective study . SEAJCRR. (2013), [cited December 12, 2017]; 2(4): 218-228.



Harvard Style

Gajjar, D. M. D., Shah, D. S. D., C.Shah, D. M., Bhatnagar, D. N. M., Soni, D. S. & Patel, D. (2013) Efficacy and Cost Effectiveness of Therapeutic Plasma Exchange in patient of Guillain-Barre Syndrome A Prospective study . SEAJCRR, 2 (4), 218-228.



Turabian Style

Gajjar, Dr. M. D., Dr. Sangita D. Shah, Dr. Mamta C.Shah, Dr. Nidhi M. Bhatnagar, Dr. Shital Soni, and Dr.Tarak Patel. 2013. Efficacy and Cost Effectiveness of Therapeutic Plasma Exchange in patient of Guillain-Barre Syndrome A Prospective study . The Southeast Asian Journal of Case Report and Review, 2 (4), 218-228.



Chicago Style

Gajjar, Dr. M. D., Dr. Sangita D. Shah, Dr. Mamta C.Shah, Dr. Nidhi M. Bhatnagar, Dr. Shital Soni, and Dr.Tarak Patel. "Efficacy and Cost Effectiveness of Therapeutic Plasma Exchange in patient of Guillain-Barre Syndrome A Prospective study ." The Southeast Asian Journal of Case Report and Review 2 (2013), 218-228.



MLA (The Modern Language Association) Style

Gajjar, Dr. M. D., Dr. Sangita D. Shah, Dr. Mamta C.Shah, Dr. Nidhi M. Bhatnagar, Dr. Shital Soni, and Dr.Tarak Patel. "Efficacy and Cost Effectiveness of Therapeutic Plasma Exchange in patient of Guillain-Barre Syndrome A Prospective study ." The Southeast Asian Journal of Case Report and Review 2.4 (2013), 218-228. Print.



APA (American Psychological Association) Style

Gajjar, D. M. D., Shah, D. S. D., C.Shah, D. M., Bhatnagar, D. N. M., Soni, D. S. & Patel, D. (2013) Efficacy and Cost Effectiveness of Therapeutic Plasma Exchange in patient of Guillain-Barre Syndrome A Prospective study . The Southeast Asian Journal of Case Report and Review, 2 (4), 218-228.



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